The Best Organic Chemistry Textbook [A Definitive Guide] 1 Which is The Best Organic Chemistry Book? 2 Summary Table: Top 13 Textbooks 3 Complete Review of All Books 3.1 1. Clayden Organic Chemistry 3.2 2. Klein Organic Chemistry 3.3 3. Organic Chemistry as Second Language 3.4 4. Advanced Organic Chemistry 3.5 5. An Introduction to General, Organic and Biological Chemistry 3.6 6. Bruice Organic Chemistry